Acid-related disorders (ARDs) such as Gastroesophageal Reflux Disease (GERD), peptic ulcer disease (PUD), NSAID-induced ulcers, and Helicobacter pylori infection remain among the most common gastrointestinal…
Pain Management
Pain Management
Pain Management
Pain Management
Background Urolithiasis is a common condition with high recurrence rates and significant healthcare burden. Despite advances in surgical and pharmacological management, effective chemolytic options remain limited, particularly for calcium-based stones. This has led to increasing patient interest in alternative therapies such as Phyllanthus niruri, a widely used herbal remedy with purported anti-urolithic effects but limited […]
Pain Management
Background Urolithiasis is a prevalent urological disorder with high recurrence rates and significant morbidity. Conventional management strategies, including surgical and pharmacological interventions, are often associated with cost, invasiveness, and adverse effects. This has led to increasing interest in plant-based therapeutics. Phyllanthus niruri, traditionally used across Ayurveda, Traditional Chinese Medicine, and ethnomedicine, has gained attention for […]
Pain Management
Background: Urolithiasis is a highly prevalent condition with recurrence rates exceeding 50% within 10 years. Stone formation results from complex interactions involving crystal aggregation, tubular epithelial adhesion, and metabolic abnormalities. Despite advances in surgical management such as extracorporeal shock wave lithotripsy (ESWL), residual fragments and recurrence remain common challenges. Phyllanthus niruri (Chanca Piedra), a medicinal plant traditionally […]
Pain Management
Background: Diuresis plays an important role in the prevention and management of urolithiasis by promoting urinary flow and facilitating the elimination of crystals and solutes. Phyllanthus niruri (Chanca Piedra) has been traditionally used for its antilithiatic and diuretic properties; however, experimental evidence supporting these effects remains limited. Objective: To evaluate the diuretic activity and sodium excretion-enhancing […]
Pain Management
Background: Calcium oxalate (CaOx)–induced renal injury is a key pathogenic process in urolithiasis and contributes to progressive renal dysfunction. Renal tubular epithelial cell damage, oxidative stress, and lipid nephrotoxicity play central roles in crystal retention and stone formation. Phyllanthus niruri L. (PN), a traditional medicinal plant used in urolithiasis, has demonstrated renoprotective properties; however, its molecular mechanisms […]
Pain Management
Background Urolithiasis is a common condition with high recurrence rates and significant healthcare burden. Despite advances in surgical and pharmacological management, effective chemolytic options remain limited, particularly for calcium-based stones. This has led to increasing patient interest in alternative therapies such as Phyllanthus niruri, a widely used herbal remedy with purported anti-urolithic effects but limited […]
Pain Management
Background Urolithiasis is a prevalent urological disorder with high recurrence rates and significant morbidity. Conventional management strategies, including surgical and pharmacological interventions, are often associated with cost, invasiveness, and adverse effects. This has led to increasing interest in plant-based therapeutics. Phyllanthus niruri, traditionally used across Ayurveda, Traditional Chinese Medicine, and ethnomedicine, has gained attention for […]
Pain Management
Background: Urolithiasis is a highly prevalent condition with recurrence rates exceeding 50% within 10 years. Stone formation results from complex interactions involving crystal aggregation, tubular epithelial adhesion, and metabolic abnormalities. Despite advances in surgical management such as extracorporeal shock wave lithotripsy (ESWL), residual fragments and recurrence remain common challenges. Phyllanthus niruri (Chanca Piedra), a medicinal plant traditionally […]
Pain Management
Background: Diuresis plays an important role in the prevention and management of urolithiasis by promoting urinary flow and facilitating the elimination of crystals and solutes. Phyllanthus niruri (Chanca Piedra) has been traditionally used for its antilithiatic and diuretic properties; however, experimental evidence supporting these effects remains limited. Objective: To evaluate the diuretic activity and sodium excretion-enhancing […]
Pain Management
Background: Calcium oxalate (CaOx)–induced renal injury is a key pathogenic process in urolithiasis and contributes to progressive renal dysfunction. Renal tubular epithelial cell damage, oxidative stress, and lipid nephrotoxicity play central roles in crystal retention and stone formation. Phyllanthus niruri L. (PN), a traditional medicinal plant used in urolithiasis, has demonstrated renoprotective properties; however, its molecular mechanisms […]
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