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Lifitegrast
5%
Dosage Form & Strength
1 drop in affected eye(s) twice daily (~12 hours apart)
Dosage in Special Population
Adults Half Life: ~2–3 hours (tear film); plasma t½ ~8 hours
Xiidra
Dry eye disease
Hypersensitivity to lifitegrast or components
Instillation site irritation, dysgeusia
Contact lens wearers: wait 15 min after instillation Long term use duration
No significant interactions known
LFA-1 antagonist; reduces T-cell activation and inflammation
Reduces inflammation associated with chronic dry eye Low Bioavailability
Minimal systemic absorption Hydrolyzed by nonspecific esterases Metabolism Primarily fecal; minor renal excretion
Category C (Use if benefit > risk)
No dose adjustment needed
No dose adjustment needed
Safety not established (<17 yrs)
No dose adjustment needed
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