Searching...
Can't find what you're looking for. Try different keywords.
Stay Informed, Stay Ahead
Ciclopirox Olamine
1%
Civaderm XL Cream is indicated for the treatment of Fungal Infections
Pharmacokinetic studies in men with tagged Ciclopirox solution in polyethylene glycol 400 showed an average of 1.3% absorption of the dose when it was applied topically to 750 cm2 on the back followed by occlusion for 6 hours. The biological half-life was 1.7 hours and excretion occurred via the kidney. Two days after application only 0.01% of the dose applied could be found in the urine. Fecal excretion was negligible. Penetration studies in human cadaverous skin from the back, with Ciclopirox olamine cream with tagged Ciclopirox showed the presence of 0.8 to 1.6% of the dose in the stratum corneum 1.5 to 6 hours after application. The levels in the dermis were still 10 to 15 times above the minimum inhibitory concentrations. Ciclopirox penetrates into the hair and through the epidermis and hair follicles into the sebaceous glands and dermis, while a portion of the drug remains in the stratum corneum.
Subscribe to our newsletter and be the first to receive insights, updates, and expert tips on optimizing your financial management.
