Volstar 10/20

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Volstar 10/20

Vonoprazan

10 mg / 20 mg

Dosage Form & Strength

10–20 mg once daily

Overview

VOQUEZNA

Dosage in Special Population

Adults

Indications

GERD, erosive esophagitis, acid-related disorders

Contraindications

Hypersensitivity to vonoprazan

Adverse Effects

Diarrhea, constipation, abdominal pain, nausea

Special Warnings & Precautions

Monitor long-term acid suppression

Drug Interactions

May affect pH-dependent drugs; CYP3A4 interactions

Mechanism of Action

Potassium-competitive acid blocker (P-CAB)

Pharmacokinetics

Potent and sustained acid suppression Half Life: ~7–9 hours

Absorption, Distribution, Metabolism & Excretion

Rapid oral absorption High Bioavailability Hepatic (mainly CYP3A4) Metabolism Fecal and renal Excretion

Drug Use in Pregnancy

There are no adequate and well-controlled studies

Drug Use in Renal Impairment

Usually no adjustment

Drug Use in Hepatic Impairment

Caution in severe hepatic impairment

Drug Use in Pediatric Population

Safety not established

Drug Use in Geriatric Population

Generally no adjustment