Best Seller Briglo serum

Briglo serum

Azelaic Acid

Niacinamide

Tranexamic Acid

Liposomal 4-Butylresorcinol

0.8%

Microencapsulated Retinol

Sepiwhite MSH

Vitamin C

Dosage Form & Strength

Apply once nightly to affected areas or as directed

Dosage in Special Population

Use cautiously in sensitive skin; gradual introduction recommended Duration: Usually 8–12 weeks for visible improvement; maintenance may be continued

Indications

Melasma, post-inflammatory hyperpigmentation (PIH), uneven skin tone, dark spots, photoaging

Contraindications

Hypersensitivity to retinoids, azelaic acid, or any formulation component

Adverse Effects

Mild irritation, erythema, dryness, peeling, transient burning/stinging

Special Warnings & Precautions

Daily sunscreen use mandatory; patch test recommended; avoid eyes and mucosa

Drug Interactions

Avoid concurrent use with strong exfoliants, high-strength retinoids, or irritating acids unless supervised

Mechanism of Action

Liposomal delivery enhances penetration. Azelaic acid, tranexamic acid, niacinamide, Sepiwhite MSH and whitonyl derivatives inhibit melanogenesis. Retinol accelerates epidermal turnover. Antioxidants and peptides improve skin renewal and texture.

Pharmacokinetics

Primarily local dermal action; minimal or no systemic exposure expected

Absorption, Distribution, Metabolism & Excretion

Topical dermal absorption Biodiversity: Minimal systemic availability expected Local skin metabolism Negligible systemic excretion

Drug Use in Pregnancy

Avoid during pregnancy due to retinol content unless physician-approved

Drug Use in Renal Impairment

No adjustment usually required

Drug Use in Hepatic Impairment

No adjustment required

Drug Use in Pediatric Population

Not routinely recommended in young children

Drug Use in Geriatric Population

Generally well