Best Seller Trioptic

Trioptic

Brimonidine

0.2%

Brinzolamide

Timolol

0.5%

Dosage Form & Strength

1 drop in affected eye(s) twice daily (~12 hours apart)

Dosage in Special Population

Adults Brimonidine ~2–3 h; Brinzolamide ~10–12 h; Timolol ~4–5 h – Half life

Indications

Open-angle glaucoma or ocular hypertension

Contraindications

Hypersensitivity; severe bronchial asthma/COPD; sinus bradycardia

Adverse Effects

Ocular irritation, dry mouth, fatigue, bradycardia, bronchospasm

Special Warnings & Precautions

Monitor HR/respiratory status; avoid abrupt withdrawal Long-term use duration

Drug Interactions

Additive effects with other glaucoma meds

Mechanism of Action

Brimonidine: α2-agonist; Brinzolamide: CAI; Timolol: β-blocker

Pharmacokinetics

Lowers IOP by decreasing aqueous humor production and increasing outflow ~60–78% (ocular) Bioavailability

Absorption, Distribution, Metabolism & Excretion

Ocular with systemic absorption Brimonidine hepatic CYP2D6; Brinzolamide unchanged; Timolol hepatic CYP2D6 Metabolism Brimonidine renal; Brinzolamide renal; Timolol renal excretion

Drug Use in Pregnancy

Category C

Drug Use in Renal Impairment

Use with caution in severe renal impairment

Drug Use in Hepatic Impairment

Use caution in severe hepatic impairment

Drug Use in Pediatric Population

Safety not established (<18 yrs)

Drug Use in Geriatric Population

No dose adjustment needed