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Eflornithine
13.9%
Elyn is indicated for the treatment of Unwanted facial hair
Most common adverse effects that occur with use of Elyn is Acne Less common side effects include Pseudofolliculitis barbae, alopecia, stinging skin*, burning skin*, dry skin, pruritus, erythema*, tingling skin, irritated skin, rash, folliculitis.
It is not known if Eflornithine has any interaction with other topically applied drug products
Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme involved in the production of the hair shaft by the hair follicle. It has been shown to reduce the rate of hair growth
Steady state cutaneous penetration of eflornithine in women from Vaniqa on facial skin of shaving women was 0.8%. The steady state plasma half-life of eflornithine was approximately 8 hours. Steady state was reached within four days. The steady state peak and trough plasma concentrations of eflornithine were approximately 10 ng/ml and 5 ng/ml, respectively. The steady state 12-hour area under the plasma concentration versus time curve was 92.5 ng.hr/ml. Eflornithine is not known to be metabolised and is eliminated primarily in the urine.
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