Best Seller Briglo Gel

Briglo Gel

AC Azelaic Acid Liposome

Actosome Whiteon (liposomal 4-butylresorcinol)

0.8%

Bio-Placenta

Tranexamic Acid

Niacinamide

Specwhite GA

0.1%

Sepiwhite MSH

Bellis Perennis Extract

Gwhite VC (3-O-Ethyl Ascorbic Acid)

Diacetyl Boldine

Sodium Hyaluronate

0.3%

Dosage Form & Strength

Apply once daily in morning or as directed by physician

Dosage in Special Population

Use cautiously in sensitive skin Duration of use: 8–12 weeks or longer depending on severity of pigmentation

Indications

Melasma, PIH, hyperpigmentation, dull skin, uneven complexion

Contraindications

Hypersensitivity to any ingredient

Adverse Effects

Mild irritation, redness, dryness, itching, burning sensation

Special Warnings & Precautions

Use broad-spectrum sunscreen; avoid contact with eyes; discontinue if severe irritation occurs

Drug Interactions

No major clinically significant interactions known; caution with irritant topicals

Mechanism of Action

Multi-target inhibition of melanogenesis through azelaic acid, tranexamic acid, niacinamide, Sepiwhite MSH, diacetyl boldine and botanical lightening agents. Liposomal delivery improves penetration while hyaluronic acid supports hydration.

Pharmacokinetics

Primarily local dermal activity; systemic exposure expected to be minimal

Absorption, Distribution, Metabolism & Excretion

Topical dermal absorption Bioavailability: Minimal systemic availability expected Local skin metabolism Negligible systemic excretion

Drug Use in Pregnancy

Use under medical supervision during pregnancy

Drug Use in Renal Impairment

No adjustment usually required

Drug Use in Hepatic Impairment

No adjustment required

Drug Use in Pediatric Population

Safety not established in children

Drug Use in Geriatric Population

Generally well