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Netarsudil
0.02%
Latanoprost
0.005%
Rocklatan
1 drop in affected eye(s) once daily (evening)
Adults Netarsudil ~1–2 h; Latanoprost ~17 min active – Half Life
Open-angle glaucoma or ocular hypertension
Hypersensitivity to components
Conjunctival hyperemia, corneal verticillata, eye irritation
May cause conjunctival hyperemia; monitor IOP Long-term use duration
May increase effect of other IOP-lowering agents
Netarsudil: ROCK inhibitor; Latanoprost: PGF2α analogue
Lowers IOP by increasing trabecular and uveoscleral outflow ~60–80% (ocular) Bioavailability
Ocular with minimal systemic absorption Netarsudil hydrolytic metabolism; Latanoprost hydrolyzed by esterases Renal/fecal excretion
Category C
No dose adjustment needed
No dose adjustment needed
Safety not established (<18 yrs)
No dose adjustment needed
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