Searching...
Can't find what you're looking for. Try different keywords.
Stay Informed, Stay Ahead
Griseofulvin
500 mg
Zorbax 500 Ultra Micronized is indicated for the treatment of Fungal Infections
Microbiology – Griseofulvin is fungistatic with in vitro activity against various species of Microsporum, Epidermophyton and Trichophyton. It has no effect on bacteria or other genera of fungi.
Absorption: The absorption of griseofulvin from the gastrointestinal tract is varaible and incomplete. On average, less than 50% of the oral dose is absorbed, but administration after a fatty meal, and a reduction in particle size will increase the rate and extent of the absorption. Distribution: The volume of distribution is about 0.7 L / Kg, and griseofulvin is ca 80 % bound to plasma proteins, predominantly serum albumin. Griseofulvin crosses the placenta, and may be excreted in breast milk. There is selective deposition of griseofulvin in newly formed keratin of hair, skin, and nails, which gradually moves to the surface of these appendages. Metabolism: Griseofulvin undergoes metabolism to inactive metabolites, principally 6- desmethylgriseofulvin, or its glucuronide conjugate. Excretion: The terminal plasma half life ranges from 9.5-21 hours, with considerable intersubject variability. The majority of the dose, as 6-desmethylgriseofulvin or the glucuronide conjugate, and other metabolites is excreted in the urine, with less than 1% administered dose beinge excreted as unchanged griseofulvin. The remainder of the dose, principally as metabolites, is excreted in bile and faeces. Renal insufficiency does not lead to accumulation.
Subscribe to our newsletter and be the first to receive insights, updates, and expert tips on optimizing your financial management.
