Perobar

Perobar

Benzoyl Peroxide

2.5% / 5 %

Indications

Perobar is indicated for the treatment of Acne in larger areas

Adverse Effects

Common advese effects of Benzoyl peroxide include Dry skin, Erythema Skin exfoliation (peeling), Skin burning sensation. Less common side effects are Pruritus, Pain of skin (pain, stinging), Skin irritation (irritant contact dermatitis)

Drug Interactions

No interaction studies have been performed; however, drugs with desquamative, irritant and drying effects should not be used concurrently with benzoyl peroxide gel

Mechanism of Action

Perobar Soap is a keratolytic agent with antibacterial actions. The effectiveness of benzoyl peroxide appears to be due to its antibacterial, peeling (keratolytic), and drying actions.

Absorption, Distribution, Metabolism & Excretion

The percutaneous penetration of benzoyl peroxide is low; when applied on the skin, it is completely converted into benzoic acid which is rapidly eliminated

Drug Use in Pregnancy

Fertility, pregnancy and lactation Pregnancy There are no or limited amount of data from the use of benzoyl peroxide in pregnant women. There are no published reports relating to the effects of benzoyl peroxide on reproductive function, fertility, teratogenicity, embryotoxicity, or peri- and post- natal development in animals. In widespread clinical use for the cutaneous treatment of acne vulgaris, at concentrations up to 10% w/w for several decades, benzoyl peroxide has never been associated with effects on these parameters in humans. Acnecide should only be used by a pregnant woman if clearly needed. Breast-feeding It is unknown whether benzoyl peroxide/metabolites are excreted in human milk. A risk to the new-borns/infants cannot be excluded. The preparation should not be applied on the chest to avoid accidental transfer to the infant.

Drug Use in Pediatric Population

Perobar Soap should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.