Avexa Cream/Lotion

Dosage Form & Strength

Apply thin layer 1–2 times daily or as directed

Dosage in Special Population

No dosage adjustment generally required

Indications

Chronic dermatitis, AD

Contraindications

Hypersensitivity to any ingredient

Adverse Effects

Special Warnings & Precautions

Avoid contact with eyes; discontinue if irritation occurs

Drug Interactions

No clinically significant interactions expected

Mechanism of Action

“Epidermosil® Bio PGA provides intense skin hydration by enhancing water retention within the epidermis. Oliconew® helps repair skin barrier abnormalities and regulates immune dysfunction, improving barrier integrity and skin resilience. Niacinamide supports immune regulation and maintains a healthy skin microbiome, strengthening the skin barrier and reducing environmental stress. Derma-Clera® Ascorbosilane C helps reduce inflammation and pruritus through antioxidant and soothing effects. Overall MOA: Avexa restores skin hydration, repairs the skin barrier, modulates immune responses, maintains microbiome balance, and reduces inflammation and itching, resulting in healthier and more resilient skin.”

Pharmacokinetics

minimal or no systemic absorption expected following topical application.

Absorption, Distribution, Metabolism & Excretion

Topical local absorption No to minimal bioavailability Negligible metabolism Negligible Excretion

Drug Use in Pregnancy

Generally considered safe

Drug Use in Renal Impairment

No adjustment required

Drug Use in Hepatic Impairment